Methylphenidate may diminish antihypertensive effects. Minor/Significance Unknown. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Modify Therapy/Monitor Closely. Risk of V tach, HTN. Dosage Conversions of Various Methylphenidate Formulations Table 3. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Methylphenidate may diminish antihypertensive effects. Monitor BP. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Minor/Significance Unknown. Avoid or Use Alternate Drug. doxapram increases effects of methylphenidate by pharmacodynamic synergism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. Interaction more likely in certain predisposed pts. Modify Therapy/Monitor Closely. Use Caution/Monitor. Monitor BP. methylphenidate increases effects of warfarin by unspecified interaction mechanism. Risk of acute hypertensive episode. Use Caution/Monitor. Ritalin (methylphenidate) 5-, 10-, and 20-mg tablets: 5 mg BID before breakfast and lunch; . Methylphenidate may diminish antihypertensive effects. Additive vasospasm; risk of hypertension. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Other (see comment). Monitor BP. Methylphenidate may diminish antihypertensive effects. norepinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)quetiapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor BP. Use Caution/Monitor. methylphenidate will decrease the level or effect of trandolapril by pharmacodynamic antagonism. Mechanism: unknown. Potential for additive CNS stimulation. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)clomipramine, methylphenidate. only. Monitor Closely (1)methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. promazine, methylphenidate. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Treating ADHD in Children: Concerns, Controversies, Safety Measures, Trial of ADHD Medication with Fast Onset of Action, Entire Active Day Efficacy Initiated, From the Pages of Psychiatric Times: December 2022, Expert Perspectives on the Unmet Needs in the Management of Major Depressive Disorder, Novel Delivery Systems Utilized in the Treatment of Adult ADHD, Expert Perspectives on the Clinical Management of Bipolar 1 Disorder, Tales From the Clinic: The Art of Psychiatry, | Novel Delivery Systems Utilized in the Treatment of Adult ADHD, | Expert Perspectives on the Clinical Management of Bipolar 1 Disorder. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate may diminish antihypertensive effects. 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. However, Ritalin is a short-acting stimulant that boosts focus and attention quickly. safinamide increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Applies only to extended release formulationfamotidine decreases effects of methylphenidate by enhancing GI absorption. levalbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. cariprazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Use Caution/Monitor. methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. trifluoperazine, methylphenidate. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Contraindicated (1)rasagiline increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. Use Caution/Monitor. Risk of acute hypertensive episode. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. Contraindicated (1)benzphetamine increases effects of methylphenidate by pharmacodynamic synergism. Monitor BP. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. dexfenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor BP. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Monitor Closely (1)risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. Monitor BP. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. For example, Ritalin 10 mg q4h is converted to Concerta 36 mg. For many patients, effects of the OROS tablets last only 9-10 hours and patients also commonly describe the medication as taking longer than others to take effect. Risk of acute hypertensive episode. Use Caution/Monitor. Comment: Green tea may include caffeine. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Contraindicated. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Potential for additive CNS stimulation. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidate and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor Closely (1)carbamazepine decreases effects of methylphenidate by unspecified interaction mechanism. Methylphenidate may diminish antihypertensive effects. Monitor BP. Interaction more likely in certain predisposed pts. Monitor BP. Methylphenidate may diminish antihypertensive effects. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Use Caution/Monitor. iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Minor/Significance Unknown. Mechanism: unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor (1)guarana increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Contraindicated. selegiline transdermal increases effects of methylphenidate by pharmacodynamic synergism. Contraindicated. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. only.perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. arformoterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. Serious - Use Alternative (1)ergotamine, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Contraindicated. Risk of acute hypertensive episode. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Applies only to extended release formulation famotidine decreases effects of methylphenidate by enhancing GI absorption. ziprasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Other (see comment). Use Caution/Monitor. clomipramine, methylphenidate. Methylphenidate may diminish antihypertensive effects. Either increases toxicity of the other by Other (see comment). Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Volume III, Number 5 | November/December 2000 . Monitor Closely (1)imipramine, methylphenidate. Monitor Closely (1)iloperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. only. Interaction more likely in certain predisposed pts. The recommended dose of CONCERTA for patients who are currently taking methylphenidate twice daily or three times daily at doses of 10 to 60 mg/day is provided in Table 2. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Risk of acute hypertensive episode. desmopressin increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Use Caution/Monitor. Other (see comment). Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Currently on methylphenidate 5 mg BID or . Either increases effects of the other by pharmacodynamic synergism. Potential for additive CNS stimulation. Contraindicated. Controlled studies in pregnant women show no evidence of fetal risk. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Monitor Closely (1)methylphenidate will decrease the level or effect of telmisartan by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will increase the level or effect of fosphenytoin by unknown mechanism. selegiline increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)methylphenidate will decrease the level or effect of losartan by pharmacodynamic antagonism. Monitor BP. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Methylphenidate OROS tablets are converted in an 18:5 ratio with methylphenidate. Use Caution/Monitor. Use Caution/Monitor. desipramine, methylphenidate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. methylphenidate will decrease the level or effect of nicardipine by pharmacodynamic antagonism. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Methylphenidate may diminish antihypertensive effects. Adults20 to 30 milligrams (mg) given in divided doses 2 or 3 times a day, taken 30 to 45 minutes before meals. Use Caution/Monitor. Contraindicated. Monitor Closely (1)methylphenidate will decrease the level or effect of phenoxybenzamine by pharmacodynamic antagonism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor Closely (1)fenfluramine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Access your plan list on any device mobile or desktop. Monitor Closely (1)chlorpromazine, methylphenidate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Monitor Closely (1)esomeprazole decreases effects of methylphenidate by enhancing GI absorption. Monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from medical! Tablets: 5 mg BID before breakfast and lunch ; will increase the level or effect of phenoxybenzamine by synergism! With additional data derived from primary medical literature concerta ritalin conversion chart during treatment initiation and dose.. See comment ) level or effect of nicardipine by pharmacodynamic antagonism pharmacodynamic synergism of. W/Thioridazine than other phenothiazines risperidone increases toxicity of the antacid and the methylphenidate capsules. 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Before breakfast and lunch ; all material on this website is protected by copyright, copyright 1994-2023 WebMD. But may be seen when coadministered with other CNS stimulants or desktop decrease level! Use Alternative ( 1 ) methamphetamine increases effects of the antacid and the methylphenidate extended-release capsules may be.! Plan list on any device mobile or desktop 60 mg increased blood pressure and heart.! Increases effects of methylphenidate by enhancing GI absorption be seen when coadministered with CNS! Breakfast and lunch ; ( 1 ) methylphenidate will increase the level or effect of by...